Amphetamine is known to inhibit monoamine oxidase, whereas the power of amphetamine and its metabolites to inhibit numerous P450 isozymes together with other enzymes has not been adequately elucidated. In vitro experiments with human microsomes indicate slight inhibition of CYP2D6 by amphetamine and minimal inhibition of CYP1A2, 2D6, and 3A4 by a n